Pharmacological and toxic effects of kryptopyrrole in mice.

Preliminary findings indicate that patients with acute intermittent porphyria excreted increased amounts of urinary kryptopyrrole during acute attacks associated with neuropsychiatric symptoms (Irvine and Wetterberg, 1971). These symptoms of acute porphyria are of special interest since they are sometimes of schizophrenic type (Waldenstrom, 1937; Peters, 1962) or constitute a porphyria mental syndrome with moderate depression, transitional confusion, visual hallucination, and neurological signs (Wetterberg, 1967).